Pdf to excel converter 6 2 14. Grade 3 AEs in the xevinapant arm that were included in the analysis were comprised of 3 patients with dry mouth (6.3%), 2 with dysphagia (4.2%), and 1 each with dysgeusia (2.1%) or deafness (2.1%). Handheld Hunting Spotlights. Grade 3 AEs in the xevinapant arm that were included in the analysis were comprised of 3 patients with dry mouth (6.3%), 2 with dysphagia (4.2%), and 1 each with dysgeusia (2.1%) or deafness (2.1%). TECH SPOTLIGHT Testing for Fatigue Crack Growth Fig. 1 — Compact Tension (CT) specimen is shown under test. Inset diagram shows the im-portant dimensions. K = P (2 + ) (0.886 + 4.64 13.32 2 + 14.72 35.6 4) B ` W (1 )3/2 a0 W B ADVANCED MATERIALS & PROCESSES/OCTOBER 2003 53 fatcrack.qxd 9/12/03 10:25 AM Page 1. Link is still to vesrion 5.1 - MacUpdate, you can't just tack the current version number on to the end of the previous version and expect it to be the new version (the file available from MacUpdate is 'HoudahSpotlatest5.1.1.zip', but decompesses to give the 5.1 version from 14 April) - this is happending far too often these days - MacUpdate you need to invest in some quality control.
- Houdahspot 3 6 4 – Advanced Front End For Spotlight Lighting
- Houdahspot 3 6 4 – Advanced Front End For Spotlight Lights
Back to Journals » Clinical and Experimental Gastroenterology » Volume 10
AuthorsFragkos KC
Received29 May 2017
![Front Front](https://www.houdah.com/houdahSpot/assets/HoudahSpot-Screenshot-Partial.jpg)
Accepted for publication 10 September 2017
Published 25 September 2017 Volume 2017:10 Pages 229—240
Wifi radar v1 5 – scan for wireless networks. DOIhttps://doi.org/10.2147/CEG.S123621
Checked for plagiarism Yes
Review bySingle anonymous peer review
Peer reviewer comments 4
Editor who approved publication: Prof. Dr. Wing-Kin Syn
Konstantinos C Fragkos
Gastrointestinal Services, University College London Hospitals, London, UK
Background: Irritable bowel syndrome with diarrhea (IBS-D) has limited options for treatment currently, including mainly anti-motility medications, antispasmodics, and antidepressants. This review discusses the properties of a new drug, eluxadoline, a gut-targeting mu- and kappa-opioid receptor agonist and a delta-opioid receptor antagonist, and its efficacy and safety in patients with IBS-D.
Materials and methods: A systematic review of the literature was undertaken to identify studies that had investigated eluxadoline as a treatment in IBS-D. A narrative review of other information is provided with respect to pharmacological and chemical properties. Where suitable, meta-analysis was performed with a random-effects model to produce a pooled estimate.
Results: Eluxadoline showed efficacy improving stool consistency (standardized mean difference [SMD]: -0.29 at 12 weeks, p = 0.0004; -0.46 at 26 weeks, p = 0.0001), global symptoms (SMD: -0.15 at 12 weeks, p = 0.006; -0.14 at 26 weeks, p = 0.02), quality of life (SMD: 0.21 at 12 weeks, p < 0.0001; 0.16 at 26 weeks, p = 0.007), pain (SMD: -0.17 at 12 weeks, p = 0.001; -0.16 at 26 weeks, p = 0.01), and adequate relief (odds ratio [OR]: 1.99 at 12 weeks, p < 0.00001; 1.78 at 26 weeks, p < 0.0001). It also improved IBS severity and other abdominal symptoms such as bloating, discomfort, and risk of urgency and fecal incontinence. Its main side effects included constipation (OR: 3.49, p < 0.00001), vomiting (OR: 3.42, p = 0.0002), abdominal pain (OR: 1.78, p = 0.007), and nausea (OR: 1.42, p = 0.07). The overall quality of trials was satisfactory with the meta-analyses providing largely homogeneous outcomes.
Conclusion: Eluxadoline’s place in clinical practice might prove useful since the pharmacological options of IBS-D are limited and eluxadoline showed a positive effect in treating the symptoms of IBS-D.
Keywords: eluxadoline, irritable bowel syndrome, diarrhea, stool consistency, pain
Gastrointestinal Services, University College London Hospitals, London, UK
Background: Irritable bowel syndrome with diarrhea (IBS-D) has limited options for treatment currently, including mainly anti-motility medications, antispasmodics, and antidepressants. This review discusses the properties of a new drug, eluxadoline, a gut-targeting mu- and kappa-opioid receptor agonist and a delta-opioid receptor antagonist, and its efficacy and safety in patients with IBS-D.
Materials and methods: A systematic review of the literature was undertaken to identify studies that had investigated eluxadoline as a treatment in IBS-D. A narrative review of other information is provided with respect to pharmacological and chemical properties. Where suitable, meta-analysis was performed with a random-effects model to produce a pooled estimate.
Results: Eluxadoline showed efficacy improving stool consistency (standardized mean difference [SMD]: -0.29 at 12 weeks, p = 0.0004; -0.46 at 26 weeks, p = 0.0001), global symptoms (SMD: -0.15 at 12 weeks, p = 0.006; -0.14 at 26 weeks, p = 0.02), quality of life (SMD: 0.21 at 12 weeks, p < 0.0001; 0.16 at 26 weeks, p = 0.007), pain (SMD: -0.17 at 12 weeks, p = 0.001; -0.16 at 26 weeks, p = 0.01), and adequate relief (odds ratio [OR]: 1.99 at 12 weeks, p < 0.00001; 1.78 at 26 weeks, p < 0.0001). It also improved IBS severity and other abdominal symptoms such as bloating, discomfort, and risk of urgency and fecal incontinence. Its main side effects included constipation (OR: 3.49, p < 0.00001), vomiting (OR: 3.42, p = 0.0002), abdominal pain (OR: 1.78, p = 0.007), and nausea (OR: 1.42, p = 0.07). The overall quality of trials was satisfactory with the meta-analyses providing largely homogeneous outcomes.
Conclusion: Eluxadoline’s place in clinical practice might prove useful since the pharmacological options of IBS-D are limited and eluxadoline showed a positive effect in treating the symptoms of IBS-D.
Keywords: eluxadoline, irritable bowel syndrome, diarrhea, stool consistency, pain
This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.
Download Article [PDF]